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47 Its prevalence has been increasing with time and is currently estimated to be around 0.01 to 0.02 per 100,000 people in the population as a whole

A key event is the blood-retinal barrier disruption, with loss of pericytes and endothelial cells, leading to microaneurysms, increased vascular permeability, and capillary obstruction, resulting in poor oxygen distribution in the retina (Wang and Lo, 2018

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WB revealed that the protein levels of HDAC1, HDAC2, and HDAC6 increased and that the protein level of ILF3 decreased after stimulation with different concentrations of simvastatin (Fig