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Scoring of histopathological findings and statistical analysis results are presented in Fig

Enzymatic proteins are involved in the protective mechanism of an organism

Senile osteoarthritis regulated by the gut microbiota: from mechanisms to treatments

Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice

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Based on the phenomena directly observed in the OA model, the mechanisms verified in other chronic inflammatory/degenerative diseases [such as rheumatoid arthritis (RA)], and reasonable inferences based on the cross-linkages of molecular pathways, we propose a hypothetical framework, suggesting that the gut microbiota-ferroptosis axis ma contribute to the progression of OA and explore the therapeutic potential of synergistic intervention measures targeting this axis