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An unfortunate side-effect of this defence machinery is that the anti-bacterial reactive oxygen species produced also react with cellular organic molecules and have the potential to induce oxidative tissue damage [46]

The rationale for many countries to introduce such fortification was to reduce the incidence of NTDs ( see above ), and it has proved remarkably successful ( Of particular note is that several cohort studies have found that high folate status (typically indicated by elevated serum folate concentrations) is associated with apparently exacerbated outcomes in individuals with low vitamin B12 status (typically indicated by low serum B12 concentration or elevated MMA concentrations), including higher risk of anemia and cognitive impairment ( With that said, several mechanistic hypotheses have been put forward to explain the putative low B12/high folate interaction

It is plausible that hyperbilirubinemia and acute favism may be two separate entities mechanistically

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Astrocytes are particularly important as they are capable of producing large amounts of GSH and cysteine, both of which are exported to support neurons in the CNS

& Fairbridge, R