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While studying human lung cells, the Salk team discovered that elevated levels of the enzyme acid ceramidase make senescent cells more susceptible to ferroptosis and can pass that vulnerability to neighboring cells

2022 Dec 20:16:4311-4323

Statements Data availability statement The data sets presented in this study can be found in online repositories

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We chose NRAS over BRAF because there is more frequent CDH1 downregulation in NRAS -mutant melanomas and a lack of targeted therapies for NRAS -mutated cases (Extended Data Fig