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Given its regenerative properties and favorable safety profile, AOD9604 holds promise as a novel therapeutic agent for OA, especially when used in conjunction with established treatments like HA [1]

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When the body is subjected to stimulation such as HS, due to the hosts decreased immunity or changes in the microenvironment, the over-proliferation of certain conditional pathogenic fungi can lead to a serious imbalance of the hosts intestinal microorganisms, which can not only cause intestinal diseases but also induce diseases outside the intestine [141, 142]

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Additional 1 H NMR signals of unknown-1 revealed the presence of one aromatic methoxy substituent, the typical signals for the -methoxy acrylate group, and aliphatic protons, similar to those for 7-HMG (Figure S4), suggesting that the structural changes are located in the ring B of the corynanthe skeleton (Figure S4)