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Description

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence

Journal of Clinical Physiology and Pathology

Vitali, G., Parente, R., and Melotti, C

Start: Begin at ~300 mcg once daily to gauge tolerability

Massberg, S

Further research indicates that this regulatory process is closely related to oxidative stress mediated by ROS and nitric oxide (NO) induced by inflammatory factors: ROS/NO promotes DMT1 expression and inhibits FPN1 function by upregulating iron regulatory protein 1 (IRP1) and hepcidin, ultimately forming a vicious cycle of iron overload-inflammation-iron retention [98]