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While small cysteine-rich neurotoxins are typically considered the main components of spider venoms, recent research has shown that spider venoms also contain many high-molecular-weight proteins, especially enzymes

doi: 10.1038/s41422-019-0164-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 7.Galluzzi L, Vitale I, Aaronson SA, et al

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Because it has a carboxylic acid moiety on the side chain, glutamic acid is one of only two amino acids (the other being aspartic acid) that have a net negative charge at physiological pH

10.1186/s12916-023-02874-y 73