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Dermal thickness, defined as the distance from the epidermaldermal junction to the dermaladipose junction or to the loose connective tissue subjacent to the panniculus carnosus, respectively, were determined at five randomly selected sites per h.p.f., as previously described 65

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Unlike Tirzepatide or Retatrutide, it does not engage GIP or glucagon receptors, making it a pure GLP-1 agonist in pharmacologic terms

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