3.3.1 Nanocarriers for topical psoriasis treatment The topical administration of antipsoriatic drugs using nanocarriers, such as liposomes, niosomes, and polymeric nanoparticles, has garnered significant research interest
CYP3A4 is thought to be the most important P450 enzyme due to its high capacity, abundance, and versatility.1 It accounts for 30% of the total liver P450 enzyme content7 and is so highly active that certain susceptible drugs can be 85% metabolized immediately following absorption, with only 15% of the drug molecules ever reaching their target organs
This is particularly concerning for older adults, postmenopausal women, and anyone with existing osteoporosis risk factors
[DOI] [PubMed] [Google Scholar] 69.Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin ER, Seifert EL, Metallo CM, Brody JR, Winter JM
HS: Visualization, Data curation, Methodology, Validation, Formal analysis, Investigation, Resources, Conceptualization, Writing review & editing, Writing original draft, Software, Supervision, Project administration
All procedures related to animal care and handling adhered to the guidelines established by the National Institutes of Health and received approval from the Animal Policy and Welfare Committee of the Naval Medical University