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Selenium is a microelement of antioxidant defense of the organism that is part of the antioxidant enzyme glutathione peroxidase, which protects membrane structures, mitochondria from peroxide lipid oxidation, has a strong immunostimulating effect, is part of the enzymes of selenoproteins, hormones, and greatly contributes to the absorption of vitamin E.

Treatment with AVE appears to interfere with these adverse effects scavenging reactive oxygen species, and protecting membrane integrity thereby conferring comprehensive protection against MMS toxicity

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These alterations are key contributors to the observed physiological changes, including elevated blood pressure