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The complete chemical structure of the molecule was determined by Dorothy Hodgkin based on crystallographic data and published in 1955 [147] and 1956, [148] for which, and for other crystallographic analyses, she was awarded the Nobel Prize in Chemistry in 1964

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

doi: 10.1046/j.1365-2621.2000.00342.x 15 BishopP.PittsE

The ECM provides a scaffold for cell migration and proliferation while also sequestering growth factors and presenting them to cells in a controlled manner