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PRP and stem cell therapies represent the most extensively investigated modalities, with PRP showing durable pain and functional improvements in multiple prospective studies and randomized trials, including benefits lasting 59 years in some patients [23]

Step 1: Exposure to UV radiation generates Reactive Oxygen Species (ROS) [3] Step 2: High levels of ROS induce oxidative stress, which leads to Tyrosinase activation, the enzyme responsible for melanin synthesis

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