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Subcutaneous administration achieves brain concentrations twice plasma levels (t 1/2 ~10.5 hr) with no toxicity observed at 15 the therapeutic dose in rats

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Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Its synthetic form, exenatide, became the basis for the first approved GLP-1 agonists (U.S