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Patients with gastric cancer with elevated CEA and NNMT had significantly poorer prognosis than those with only one positive marker, suggesting that combining NNMT with other biomarkers improves clinical diagnostic accuracy (43)

Because the Slow COMT enzyme cannot clear these chemicals fast enough, the brain becomes flooded with adrenaline and dopamine

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48 This biomarker has, therefore, been proposed for the early identification of patients with pre-eclampsia at risk of developing a severe HELLP syndrome, although its clinical utility is questionable due to increased D-dimer during physiological pregnancy (see above)