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The absence of IGF-1 pathway activation is also consistently observed across experimental systems, reinforcing its value in studies requiring separation of metabolic and growth-related signaling pathways

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Although some theorize that Tesamorelin's effects might be related to molecules like IGF-1, the study did not find a notable connection between changes in IGF-1 levels and shifts in muscle size or density

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All three affect fat in some way, but they work differently and are not interchangeable

It can also make maintaining the result more difficult