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PA and propionyl-CoA exert profound neurotoxicity by disrupting cellular energy metabolism and mitochondrial function, primarily through broad-spectrum inhibition of key metabolic enzymes, including pyruvate dehydrogenase (PDH) complex, KGDHC, succinyl-CoA ligase, N-acetylglutamate synthase (NAGS), Na + ,K + -ATPase, and MRC complex III (Klker et al

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Interestingly, just like its role in different kinds of cancer progression, miR-148a expression is differently regulated by various curcuminoids [48]

For those with Secondary Carnitine Deficiency (SCD), its crucial to prevent low blood sugar by eating regularly through the day and to ensure a constant supply of corn starch at night

10.1016/j.msard.2019.01.011 129 SailerM.Sweeney-ReedC

Consensus about the right duration of a VR therapy session is one more time difficult to find in the literature, but it is strategic to keep in mind the potential obstacles of VR, which can hinder efficacy and cost-effectiveness (Bevens et al., 2022