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The MET inhibitor cabozantinib and MET shRNA knockdown significantly reduced their tumourigenicity in vitro and in vivo and reduced the population of CSCs

In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading