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The binding pocket resides the catalytic threonine at the bottom of the groove on one of the central -sheets, and it further extends into the enzyme, appearing as a finger-like projection

10.1021/bi901180v 8 AxarliI

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10.1038/s41390-020-01113-x 46 GrothA.VrugtB.BrockM.SpeichR.UlrichS.HuberL

Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

The therapeutic potential of riboflavin in AIFM1-related conditions merits rigorous investigation through larger, prospective studies