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Epub 2009 Apr 29 Goyal M, Singh A, Kornak U, Kapoor S

In ACC, Wnt/-catenin pathway activation is frequent and occurs via activating mutations in the CTNNB1 gene or inactivating mutations in ZNRF3 ( CTNNB1 mutation to exhibit higher expression of LEF-1 compared to non-tumour adrenal samples and ACCs without CTNNB1 mutation ( It has been shown in ovarian and colorectal cancer that Wnt/-catenin pathway activation leads to significantly lower levels of mature CD8 + T cells

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The study sponsors were not involved in any stage of research design, execution, data analysis, manuscript preparation, or publication decisions

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