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And when it does get absorbed in large doses, it can overload the redox systemironically creating whats known as reductive stress, which can be just as harmful as oxidative stress

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The kynurenine pathway is the longest NAD + biosynthetic pathway: the catabolism of tryptophan through kynurenine produces quinolinic acid, which is then converted to nicotinic acid mononucleotide, an intermediate in NAD + metabolism