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coli , simultaneous inactivation of the GSH and thioredoxin pathways is unviable but inactivation of either pathway is fully viable, which indicate that each can fully operate the essential function of reducing disulphides in the absence of the other (reviewed in Toledano et al (2007))

doi: 10.1111/j.1476-5381.2011.01302.x 12 CooperJ

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Although glutathione reductase activity was not significantly different between the groups, fish oil supplementation resulted in a smaller increase in GR compared with the control group, suggesting a possible antioxidant effect of fish oil supplementation