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Despite increased extramedullary erythropoiesis, reticulocytes failed to mature into red blood cells and accumulated large autophagosomes with engulfed mitochondria [23]

Therefore, for SLE and LN treatment, adoptive transfer of Tregs can be directly applied, either as polyclonal Tregs or as engineered variants with a receptor of high affinity for the target autoantigen, such as TCR-Tregs or CAR-Tregs, to eliminate or deactivate aberrant immune cells and reduce inflammation in AIDs (75)

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Osteocalcin induces proliferation via positive activation of the PI3K/Akt, P38 MAPK pathways and promotes differentiation through activation of the GPRC6A-ERK1/2 pathway in C2C12 myoblast cells

Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease

BPC-157 (Body Protection Compound-157), also designated as PL-14736, is a synthetic pentadecapeptide composed of 15 amino acids: (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val)