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Description

The nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome operates as a threat-detecting intracellular platform that is required for the formation of IL-1 from its precursor pro-IL-1, and is instrumental in its cellular release through gasdermin membrane pores in response to detected DAMPs, PAMPs and harmful alterations in the cellular interior milieu, such as alterations in redox status and mitochondrial dysfunction (194)

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