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However, more research is needed to delineate how polyphenols and related metabolites, either phase II metabolites or those generated by the gut microbiota, might interact with systemic tissues, using in vitro and in vivo models [32]

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Dysfunction of the lens due to opacification is called cataract

S -lactoylglutathione itself is an intermediate in the pathway for the detoxification of methylglyoxal via the glyoxalase system ( All EstD homologs possess a conserved cysteine that is situated in close proximity to the active site pocket but is not essential for enzyme activity ( N

Because GPA inhibits mouse GABA transporter 3 and 4 (GAT3/SLC6A13 and GAT4/SLC6A11) [54, 55], there is a possibility that mouse GAT3 and GAT4 mediate transport of GCs

The interaction of AGE-RAGE triggers intracellular and extracellular signaling pathways through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), NADPH oxidase, and nuclear factor-B (NF-B)