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Because Syn is a substrate of cathepsin D, and also, in its aggregated form, a principal pathological feature of PD 27 , we next investigated whether low-dose CO might affect the levels of Syn directly, and the levels of Syn phosphorylated on Serine 129 (Syn pSer129 ), a form of the protein associated with aggregates in PD patients, and also a pathological feature of PD-associated Syn A53T neurotoxicity in our rodent model 28

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Tobacco use restricts blood flow which, if left untreated, can lead to gangrene (death of body tissue) and amputation of affected areas

In this case, check the moistness of your tobacco and whether youve packed it properly

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