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Polyol pathway and diabetic peripheral neuropathy

Delitala G, Palermo M, Ross R, Coy D, Besser M, Grossman A

Known for its structural modificationsspecifically a substitution of arginine at position 3 and a 13-amino acid extensionIGF-1 LR3 is designed to resist binding proteins and increase bioavailability in research settings

doi: 10.1038/nrm3735 57 YamaguchiHWangHG

Ethics declarations Conflict of interest The authors declare no potential conflict of interest

Lysosomal free cholesterol is impaired in APOE 3/4 + PSEN1 fibroblasts Several studies underscore that alterations in cholesterol metabolism are involved in the pathogenesis of AD (Wood et al., 2014