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J Neurosci 32:1033110337

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In A Counterblaste to Tobacco (1604), he famously describes smoking as a custome lothsome to the eye, hatefull to the nose, harmefull to the braine, dangerous to the lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoake of the pit that is bottomelesse. 48 FIGURE 13.3 Europeans took up smoking tobacco through small pipes: ( left ) an English smoker

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nAChRs routinely and intermittently upregulate or modify the subunit composition of brain structures that go through essential stages of differentiation and synaptogenesis throughout early critical developmental periods [23]