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Daratumumab and Isatuximab are conventional CD38-specific mAbs, both derived from human CD38-immunized mice

Although we did not directly measure serum or tissue levels of these agents in these mice, both interventions were associated with improvement in systemic AGE-related measures and metabolic indices, consistent with their intended modes of action, and their combination offered limited additional benefit beyond specific endpoints

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The restorative effect in damaged diabetic nerves versus the irritative effect in healthy nerves reconciles the improve-neuropathy / cause-dysesthesia split

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