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Public health practitioners can use these insights to design interventions that address the unique challenges of long-term smokers

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Additionally, differences in risk between cigar and cigarette smokers has been attributed for years to differences in inhalation practices [6, 26, 27]

Recent evidence indicates that smoking induces the expression of a mediator known as mdig, which in turn alters the transcription of several key proteins that have been implicated in development of COVID-19 Despite its negligible effects on the expression of ACE2 and TMPRSS2 in endothelial cells [1], cigarette smoking is still associated with increased risk of severe COVID-19

Although research on this type of habit is limited, experts are adamant: cigarettes remain the leading preventable cause of disease and death, and even occasional smoking carries risks most notably the risk of addiction