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[19] But as one RJR Reynolds researcher said in 1982, If a man has never smoked by age 18, the odds are three-to-one he never will

"Big Tobacco, Tiny Targets"

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This degree of tissue change is directly dependent upon the type of smokeless tobacco (leaf versus finecut), the specific brand of tobacco, the size of the pinch of tobacco, and the length of time the pinch is in contact with the mouth tissues

These abnormal nerve growths indicate serious nerve injury

Once addiction takes hold, users find themselves compelled to use nicotine to avoid withdrawal symptoms and to maintain the pleasurable effects, creating a reinforcing cycle of dependence