tobacco is a stimulant or depressant Is Nicotine Stimulant Depressant? Clinical Effects of Cigarette Smoking:

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173 Defensins can efficiently eliminate bacteria via membrane depolarization and premature activation of cell wall lytic enzymes, 174 while the antimicrobial effects of the cationic human cathelicidin LL-37 depend on their capacity to attract monocytes, neutrophils and CD4 + T cells and activate mast cells

Women at higher risk The estimates were found to be higher in women who smoked between one and five cigarettes per day: 57% (all studies) to 119% (studies controlling for confounders) increased risk for heart disease, and 31% for stroke, compared with women who never smoked

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