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Phosphorylated R-Smads bind to the co-mediator Smad4 to form a complex, which translocates into the nucleus and initiates the transcription of target genes that are mainly involved in inhibiting cell proliferation, promoting apoptosis and maintaining vascular homeostasis (Humbert et al

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Sales and use tax revenues grew and, like most economic measures in the state, peaked in FY2006 and FY2007 at $793

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