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Figure 4 5,10-methylene-THF can be reduced by MTHFR into 5-methyl-THF, that enters methyl cycle where the one-carbon group of 5-methyl-THF is utilized by methionine synthase in the conversion of homocysteine (Hcy) to methionine

Gallen with early stage breast cancer

doi:10.1016/j.expneurol.2016.06.005

Although siRNA studies show that GSTO1 is important for HCT116 cancer cell viability, knockdown of GSTO1 did not appear to affect C1-27 cytotoxicity, suggesting that other targets of C1-27 also may contribute to its cytotoxicity and have a compensatory effect (Supplementary Fig