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4.2 Graves Disease/Thyroid Eye Disease (TED) In Graves disease, auto-Abs and antigen-specific T cells react to the thyroid-stimulating hormone receptor [153]

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Other enzymes of the AKR family for which aldehyde reducing capabilities have been established include AKR1C1 and its rat homolog AKR1C9, which have been shown to efficiently catalyze the oxidation of 4-HNE in vitro (190)