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R., Thorneycroft, I

However, the dosing regimen has to be adjusted to maximize concentration of glutathione in the blood and bioavailability studies are warranted prior to designing the treatment protocol

Additionally, challenges in accessing clinical samples have confined most treatment strategies to the preclinical stage

(2003) demonstrated the importance of time-specific efflux pump functionality showing that the highest levels of transcription and, therefore, efflux pump expression occurred early in biofilm development, and that this was a coordinated response of several efflux pumps causing increased levels of resistance

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Febs Lett, 115: 253-256