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Subsequent genome-wide association studies have confirmed this hypothesis by showing increased expression of specific genes encoding HLA-DR and reduced DNA methylation (Nalls et al., 2011)

R.ClarkeS

Tan H, Chen J, Li Y, Li Y, Zhong Y, Li G

We advocate that future AD research must establish a comprehensive framework that integrates iron metabolism, oxidative stress, and A/tau pathology to transcend the limitations of the traditional amyloid-centric hypothesis, thereby achieving a more holistic understanding of AD pathogenesis