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5 The guidelines recommend the onset of early treatment with therapeutic drugs such as synthetic and biological disease-modifying anti-inflammatory drugs (DMARDs), which include biological DMARDs like certolizumab pegol, etanercept, and adalimumab as well as traditional synthetic DMARDs like leflunomide, methotrexate (MTX), and also sulfasalazine

At a first glance, yes

Researchers have identified that heterozygous functional loss mutations in the KCNK3 gene (member 3 of the potassium channel subfamily K) are responsible for hereditary PAH, as KCNK3 encodes an outwardly rectifying potassium (K +) channel [87, 88]