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Mehak Gulzar: Writing- Original draft preparation, Investigation, Methodology

It's a combination of the GHK peptide and a copper ion, which gives it a blue color

122 The STAT family consists of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6

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1 Introduction Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus, affecting an estimated 30%40% of diabetic patients and serving as the leading cause of end-stage renal disease (ESRD) globally ( Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and characterized by the accumulation of iron and reactive oxygen species ( Acteoside (ACT), a natural phenylpropanoid glycoside abundant in Rehmannia glutinosa and other medicinal herbs, possesses potent antioxidant, anti-inflammatory, and antifibrotic properties ( in vivo studies have demonstrated that ACT ameliorates renal interstitial fibrosis and improves kidney function in streptozotocin-induced DN models, reducing serum creatinine and blood urea nitrogen levels while attenuating histopathological damage ( Network pharmacology enables systematic mapping of bioactive compounds, targets, and signaling pathways, shedding light on the mechanisms by which traditional Chinese medicines act in complex disorders ( in silico pharmacology predictions, we conducted in vivo experiments in STZ-induced DN mice

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