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Conclusion: Our results indicate a protective effect of IGF-1 against OA pathogenesis by inhibition of NF-B signaling via regulation of the MAPK and PI3K/Akt signaling pathways and prevention of apoptosis by suppression of ROS production

Arch Intern Med 167(20):22492254 Cobo G et al (2017) Hypogonadism associated with muscle atrophy, physical inactivity and ESA hyporesponsiveness in men undergoing haemodialysis

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In this manuscript, we review preclinical and clinical evidence suggesting that MDs may affect fetal development and highlight the fetal and maternal outcomes that may provide a wake-up call for targeted genetic diagnosis

Further genetic studies revealed the Past-time (Psttm) mutation in FBXL21 shortens circadian period and counteracts the long-period phenotype of FBXL3 (Ovtm) , illustrating their functional antagonism (Yoo et al., 2013)