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For instance, the extent of DNA double-strand breaks is reflected by the increase in H2AX, an early step in the DNA damage response (DDR) machinery [50]

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Combined cigarette-cigar smokers have an overall lung cancer mortality ratio of 11.20 (NCI, 1998)

Sale and importation were both banned

But by 1952, the authors would make the stark prediction in JAMA that because of the continuous increase in rates of cigarette smoking, lung cancer would soon surpass stomach cancer as the most frequently diagnosed cancer