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10.1007/s00401-009-0619-8 114 SpickettC

Rather than simply blocking these enzymes, copper peptides promote the synthesis of tissue inhibitors of metalloproteinases (TIMPs), creating a balanced environment where old, damaged collagen is removed while new, healthy collagen is produced

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The toxic anthraquinones and their metabolic activation are clearly shown in Table 1

Braz J Plant Physiol 17(1):3552

Remember that supplements complement, but don't replace, fundamental health practices like maintaining healthy weight, limiting alcohol intake, eating a nutrient-dense diet, and managing metabolic health