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Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H (2015) I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway

It has been one of the most extensively studied peptides in preclinical gastroenterology and tissue biology research, with over 100 published animal studies examining its effects across multiple organ systems

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Substantial heterogeneity in animal models, exposure conditions, and microbiota assessment methods further limits cross-study comparability (Table 5S

doi: 10.1002/hep.20948

Tirzepatide (GLP-1/GIP) Tirzepatide is a first-in-class dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist, providing synergistic metabolic effects for diabetes and obesity research