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Vitamin C is thought to be an important water soluble antioxidant which is reported to neutralize ROS and reduce the oxidative stress [8, 10]

Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Wu et al., 2016) and damages the cytoskeleton, along with other physiological processes related to insulin signaling

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In total, we performed 11 rounds of selection over three generations of evolution (Fig

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Methylated B vitamins address this directly and as the pathway diagram shows, adequate B12 and folate are also prerequisites for healthy cysteine production upstream of the glutathione system