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Leuk Lymphoma 63(7):1580-1588, 2022

Cotsiranib is a siRNA therapy developed by Sirnaomics that uses the PNP delivery platform, containing two active siRNAs targeting TGF1 and cytochrome C oxidase subunit 2 mRNA

Following reduction of the ketone group at the sn -2 position to make 1-alkyl- sn -glycero-3-phosphate by an acyl/alkyl-DHAP reductase (DHRS7B, dehydrogenase/reductase 7B), which is located primarily in peroxisomes and partly in the ER requiring NADPH as a cofactor

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It plays a central role in redox homeostasis, detoxification of reactive oxygen species, and maintenance of cellular thiol balance across virtually every tissue type in the body