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First, the chemical identification was performed once, with the methodology of the 1970s, and was not subsequently re-verified by modern peptide sequencing a point Kovalzon and Strekalova later flagged as a source of doubt about whether the isolated nonapeptide was a single defined entity or a mischaracterized fraction of a larger precursor (Kovalzon & Strekalova, 2006)

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However, each approach has its limitations

Selon la Harvard Medical School, les personnes prsentant un dficit en cobalamine peuvent ressentir des signes discrets mais progressifs, tels que des picotements ou un engourdissement, des difficults marcher, des troubles cognitifs ou de la mmoire, ainsi quune sensation de faiblesse