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B12 injections are key for people with certain health issues

NNMT uses up nicotinamide by tagging it with a methyl group (a process called methylation) and sending it out as waste

NNMT is highly expressed in adipose tissue and plays a role in cellular methyldonor economy and nicotinamide processing

Others suggest additional benefits such as antimicrobial and antioxidant activities, enhanced immunity, and reduced inflammation

5-Amino-1MQ, by contrast, improves insulin sensitivity through AMPK activation, which means it will alter glucose handling as part of its metabolic reprogramming effect

The trial was powered to detect a 1.8 kg difference vs placebo