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Persistent very high levels (for example, sustained above 3 SDS in clinical context) may need clinician review, dose adjustment, or stopping

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POTENTIAL MECHANISMS UNDERLYING THE DECLINE IN GH SECRETION WITH AGE Three hypothalamic factors regulate GH secretion: somatostatin (Somatotropin Release-Inhibiting Factor, SRIF), growth hormone-releasing hormone (GHRH), and ghrelin (11) (Figure 2)

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After 2 weeks of treatment, we observed a significant reduction in tumour volume in the palbociclib + RSL3-treated mice when compared with all other groups (Fig

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