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Supports investigation of tissue structural rejuvenation: Accumulated senescent cells can impair tissue architecture by altering cell-to-cell communication and extracellular matrix composition

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Possible clinical applications are women with central obesity, HIV-associated lipodystrophy, or metabolic syndrome in which visceral fat negatively affects reproductive outcomes

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Isoniazid, cycloserine, penicillamine, hydralazine: These drugs act as Pyridoxine antagonists and lower B6 levels in the body