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Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function

The study protocol was approved by the Institutional Review Board of Bhumibol Adulyadej Hospital and was registered in the Thai Clinical Trials Registry (TCTR)

All experimental techniques were accepted and supervised by the Animal Care and Use Committee of the Faculty of Pharmacy, Al-Azhar University, with ethical approval number 429/2023

This makes it a powerful tool for individuals struggling with metabolic syndrome, insulin resistance, or age-related metabolic decline

However, efforts must also focus on the interim strategy to slow neuron losses in brain structures impacted including neocortices, hippocampus, locus ceruleus and the nucleus basalis of Meynert by stimulating synaptogenesis, neurogenesis and reducing neuroinflammation and oxidative stress

Mueller LL