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Oxidative stress occurs when the production of reactive oxygen species (ROS) or free radicals exceeds the bodys ability to neutralize them with antioxidants

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It reduces the B-cell population besides affecting cytokine production [155, 156]

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In contrast, digoxin has a TI of only about 2, and for such drugs toxicity may be precipitated by relatively small changes in dosage regimen or the clearance of the drug from the body